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1

Maximize tube life by using internal and external inspection devices

Richard D. Roberts, John Brightling

Journal:

Process Safety Progress

Year:

2005

Language:

english

File:

PDF, 1.02 MB

english, 2005

2

Sputum microbiome profiling in COPD: beyond singular pathogen detection

Ditz, Benedikt, Christenson, Stephanie, Rossen, John, Brightling, Chris, Kerstjens, Huib A M, van den Berge, Maarten, Faiz, Alen

Journal:

Year:

2020

Language:

english

File:

PDF, 446 KB

english, 2020

3

Human Airway Smooth Muscle Cells from Asthmatic Individuals Have CXCL8 Hypersecretion Due to Increased NF- B p65, C/EBP , and RNA Polymerase II Binding to the CXCL8 Promoter

John, A. E., Zhu, Y. M., Brightling, C. E., Pang, L., Knox, A. J.

Journal:

The Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 2.75 MB

english, 2009

4

Abnormal Histone Methylation Is Responsible for Increased Vascular Endothelial Growth Factor 165a Secretion from Airway Smooth Muscle Cells in Asthma

Clifford, R. L., John, A. E., Brightling, C. E., Knox, A. J.

Journal:

The Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 2.40 MB

english, 2012

5

Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma

Thomas, Biju, Rutman, Andrew, Hirst, Robert A., Haldar, Pranab, Wardlaw, Andrew J., Bankart, John, Brightling, Christopher E., O'Callaghan, Christopher

Journal:

Journal of Allergy and Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

6

[Ca 2+ ] i oscillations in ASM: Relationship with persistent airflow obstruction in asthma

Sweeney, David, Hollins, Fay, Gomez, Edith, Saunders, Ruth, Challiss, R.A. John, Brightling, Christopher E.

Journal:

Year:

2014

Language:

english

File:

PDF, 296 KB

english, 2014

7

Integrin v 5-Mediated TGF- Activation by Airway Smooth Muscle Cells in Asthma

Tatler, A. L., John, A. E., Jolly, L., Habgood, A., Porte, J., Brightling, C., Knox, A. J., Pang, L., Sheppard, D., Huang, X., Jenkins, G.

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 1.56 MB

english, 2011

8

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

Clifford, Rachel L., Patel, Jamie K., John, Alison E., Tatler, Amanda L., Mazengarb, Lisa, Brightling, Christopher E., Knox, Alan J.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2015

Language:

english

File:

PDF, 368 KB

english, 2015

9

Characterization of acinar airspace involvement in asthmatic patients by using inert gas washout and hyperpolarized 3helium magnetic resonance

Gonem, Sherif, Hardy, Steven, Buhl, Niels, Hartley, Ruth, Soares, Marcia, Kay, Richard, Costanza, Rino, Gustafsson, Per, Brightling, Christopher E., Owers-Bradley, John, Siddiqui, Salman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

10

Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma

Sutcliffe, Amanda, Hollins, Fay, Gomez, Edith, Saunders, Ruth, Doe, Camille, Cooke, Marcus, Challiss, R. A. John, Brightling, Chris E.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

11

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK): Figure 1

Heaney, Liam G, Djukanovic, Ratko, Woodcock, Ashley, Walker, Samantha, Matthews, John G, Pavord, Ian D, Bradding, Peter, Niven, Robert, Brightling, Chris E, Chaudhuri, Rekha, Arron, Joseph R, Choy, Da

Journal:

Year:

2015

Language:

english

File:

PDF, 339 KB

english, 2015

12

Comparison of CT-based Lobar Ventilation with 3 He MR Imaging Ventilation Measurements

Tahir, Bilal A., Van Holsbeke, Cedric, Ireland, Rob H., Swift, Andrew J., Horn, Felix C., Marshall, Helen, Kenworthy, John C., Parra-Robles, Juan, Hartley, Ruth, Kay, Richard, Brightling, Chris E., De

Journal:

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

13

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D31. ADVANCES IN ASTHMA GENETICS - Genome-Wide Association Study Identifies Novel Loci Associated With Reversibility To ²2 Agonist In Severe Asthma Subjects

Obeidat, Ma'en, Shrine, Nick R.G., Tobin, Martin D., Blakey, John D., Mansur, Adel, Manney, Sarah, Thomson, Neil, Chaudhuri, Rekha, Brightling, Chris E., Bafadhel, Mona, Singapuri, Amisha, Niven, Rob,

Year:

2012

Language:

english

File:

PDF, 19 KB

english, 2012

14

Airway and peripheral uPAR is elevated in asthma, and identifies a severe, non-atopic subset of patients

Portelli, Michael A, Moseley, Christopher, Stewart, Ceri E, Postma, Dirkje S, Howarth, Peter, Warner, Jane A, Holloway, John W, Koppelman, Gerard H, Brightling, Chris, Sayers, Ian

Journal:

Year:

2016

Language:

english

File:

PDF, 1.35 MB

english, 2016

15

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado - ()] A30. NOVEL MECHANISMS OF AIRWAY SMOOTH MUSCLE CONTRACTION AND RELAXATION: ARE THESE THERAPEUTICALLY TARGETABLE? - Up-Regulated Nox4 Expression Mediates Enhanced Airway Smooth Muscle Contractility In Asthma

Hollins, Fay, Sutcliffe, Amanda, Gomez, Edith, Doe, Camille, Saunders, Ruth, Challiss, John, Brightling, Christopher

Year:

2011

Language:

english

File:

PDF, 21 KB

english, 2011

16

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4

Di Candia, Leonarda, Gomez, Edith, Venereau, Emilie, Chachi, Latifa, Kaur, Davinder, Bianchi, Marco E., Challiss, R.A. John, Brightling, Christopher E., Saunders, Ruth M.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 2.41 MB

english, 2017

17

Using An Instrumental Variable Approach To Estimate Causal Treatment Effects In An Observational Cohort of Patients With Chronic Obstructive Pulmonary Disease

John, E, Abrams, KR, Sheehan, N, Brightling, C

Journal:

Value in Health

Year:

2017

Language:

english

File:

PDF, 59 KB

english, 2017

18

[BMJ Publishing Group Ltd and British Thoracic Society British Thoracic Society Winter Meeting 2017, QEII Centre Broad Sanctuary Westminster London SW1P 3EE, 6 to 8 December 2017, Programme and Abstracts - ()] Mechanisms of asthma - S86 Extracellular matrix deposited by asthmatic human airway smooth muscle cells enhances basal activation of tgfβ

Cairns, JT, Krishnan, R, John, AE, Brightling, CE, Shaw, DE, Jenkins, G, Tatler, AL

Language:

english

File:

PDF, 103 KB

english

19

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

Hanratty, Catherine E., Matthews, John G., Arron, Joseph R., Choy, David F., Pavord, Ian D., Bradding, P., Brightling, Christopher E., Chaudhuri, Rekha, Cowan, Douglas C., Djukanovic, Ratko, Gallagher

Journal:

Year:

2018

Language:

english

File:

PDF, 638 KB

english, 2018

20

Ammonia and the Fertiliser Industry: The Development of Ammonia at Billingham

Brightling, John

Journal:

Johnson Matthey Technology Review

Year:

2018

Language:

english

File:

PDF, 3.03 MB

english, 2018

21

Spread the Word About CHEST in 2019

Irwin, Richard S., Heffner, John E., Maxwell, Lisbeth, French, Cynthia L., Augustyn, Nicki, Frantsve-Hawley, Julie, Barnes, Peter J., Brightling, Christopher E., Davidson, Bruce L., Gutterman, David D

Journal:

Year:

2019

File:

PDF, 294 KB

2019

22

Composite type-2 biomarker strategy versus a symptomârisk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial

Heaney, Liam G, Busby, John, Hanratty, Catherine E, Djukanovic, Ratko, Woodcock, Ashley, Walker, Samantha M, Hardman, Timothy C, Arron, Joseph R, Choy, David F, Bradding, Peter, Brightling, Christophe

Journal:

The Lancet Respiratory Medicine

Year:

2020

File:

PDF, 718 KB

2020

23

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma

Emson, Claire, Diver, Sarah, Chachi, Latifa, Megally, Ayman, Small, Cherrie, Downie, John, Parnes, Jane R., Bowen, Karin, Colice, Gene, Brightling, Chris E.

Journal:

Respiratory Research

Year:

2020

File:

PDF, 758 KB

2020

24

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D31. ADVANCES IN ASTHMA GENETICS - Genome-Wide Association Study Identifies Novel Loci Associated With Forced Expiratory Volume In One Second (FEV1) As A Percent Of Predicted In Severe Asthma Subjects

Obeidat, Ma'en, Shrine, Nick R.G., Tobin, Martin D., Blakey, John D., Heaney, Liam, Al-Momani, Basima A., Mansur, Adel, Manney, Sarah, Thomson, Neil, Chaudhuri, Rekha, Brightling, Chris E., Bafadhel,

Year:

2012

File:

PDF, 20 KB

2012

25

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 â¢ New Orleans - ()] C108. AIRWAY SMOOTH MUSCLE CELL SIGNALING AND FUNCTION IN HEALTH AND DISEASE - Vascular Endothelial Growth Factor (VEGF) Protein Production Is Increased In Asthmatic Airway Smooth Muscle (ASM) By A Selective increase In The 165a Isoform: Role Of Sp-1 And Glycogen Synthase Kinase (GSK) Pathways

Clifford, Rachel L., John, Alison E., Brightling, Chris, Knox, Alan J.

Year:

2010

File:

PDF, 18 KB

2010

26

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 â¢ Denver Colorado - ()] C18. NOVEL MECHANISMS DRIVING AIRWAY REMODELING IN ASTHMA - Aberrant Histone Methylation And SP1 Association Are Responsible For VEGF165a Hypersecretion From Asthmatic Airway Smooth Muscle Cells (ASMCS)

Clifford, Rachel L., John, Alison E., Coward, William R., Brightling, C E., Knox, Alan J.

Year:

2011

File:

PDF, 18 KB

2011

27

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 â¢ New Orleans - ()] A98. BREAKING DOWN THE WALL: NOVEL INSIGHTS IN AIRWAY WALL REMODELING - Activation Of Transforming Growth Factor-Â² (TGF-Â²) In Response To Lysophosphatidic Acid Is Increased In Asthma

tatler, amanda L., John, Alison E., Jolly, Lisa, Brightling, Chris, Porte, Joanne, Knox, Alan J., Pang, Linhua, Jenkins, Gisli

Year:

2010

File:

PDF, 20 KB

2010

28

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 â¢ New Orleans - ()] A65. GENE EXPRESSION, PHENOTYPE, AND FUNCTION IN AIRWAY SMOOTH MUSCLE: NEW INSIGHTS - Basal Hypersecretion Of CXCL8 In Asthmatic Human Airway Smooth Muscle Cells Is Associated With Increased Binding Of Histone Acetyltransferases To The CXCL8 Promoter And Acetylation Of Histone H3

John, Alison E., Clifford, Rachel L., Brightling, Christopher E., Knox, Alan J.

Year:

2010

File:

PDF, 20 KB

2010